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High-throughput chemical screening for replicative and reproductive growth defects

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Academic Level:
Graduate Students (PhD)
Postdoc & Early Career

The United States manufactures and uses high volumes of a vast array of industrial chemicals, over 90% of which are not monitored for their potential toxicities towards human health. Many of these chemicals are structurally similar to those with known toxicities. Numerous industrial chemicals are detected in the maternal and umbilical cord sera, and are thus poised to have an impact early in development. Exposures to these unmonitored and untested chemicals in utero may also adversely impact future reproductive health, particularly in females for whom this period comprises the initial stages of gametogenesis, when the oocyte is forming. Environmental chemicals, such as pesticides and plasticizers, may affect germ cell development, particularly meiosis, the key process by which chromosomes segregate during gametogenesis. An impediment to identifying and understanding the role of industrial chemicals is the prolonged delay between toxicant exposure and the manifestation of reproductive perturbations. As a result, there is a paucity of information on reproductive toxicity. We address this need through a transdisciplinary collaboration to analyze the reproductive effects of industrial chemicals identified in maternal and umbilical cord sera using in vivo models of germ cell development. To assay effects on meiosis, we will utilize the yeast Saccharomyces cerevisiae, a unicellular organism in which meiosis is best understood to develop a high-throughput approach to screen through chemicals that are found in fetal and maternal blood.

Participating Institution(s):
(Click an institution to see all programs it hosts)
University of California, San Francisco (Lead)

Program Materials:
 • Postdoc Website this link takes you to a different website

This Program can be Described by:
Academic Disciplines:
Artificial Intelligence
Bioinformatics & Genomics
Cellular Biology
Environmental Sciences
Genetics & Genomics
Molecular Biology
Optics & Photonics

Biological & Chemical Sensors
Cellular & Molecular Imaging
Chromosome Biology
Environmental Biology
Environmental Health
Environmental Toxicity
Genomic Analysis

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This program is funded by:
National Science Foundation (NSF)
National Institute of Health (NIH)

Page last updated 9/1/2018
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