Description: A post-doctoral NIH-funded position is available in the Lipscombe Lab in the Department of Neuroscience at Brown University to study the role of alternative splicing of voltage-gated calcium ion channels in sensory neuron sensitization. The project includes assessment of epigenetic regulation of calcium ion channel gene splicing and the impact on intracellular calcium signaling in genetically distinct sensory nerve endings. The lab utilizes a range of techniques including knock-in cre mouse strains for optogenetic control of neuronal activity and 2-photon calcium imaging in vivo, molecular analyses of exon-specific epigenetic modification, and linking molecular events to behavior.
The successful candidate will have expertise in or ability to acquire skills in molecular and biochemical techniques, two-photon calcium imaging, and /or electrophysiology. Postdoctoral trainees are research partners in a vibrant brain science community with opportunities to collaborate with other laboratories. Brown also offers workshops and seminars focused on promoting the career development of postdoctoral trainees both within the Carney Institute for Brain Science as well as through Brown's Office for Postdoctoral Affairs.
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