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Research in neuroscience at UAB uses a variety of tools to study the molecular, cellular and network bases of the structure and function of the nervous system, including molecular genetics, single cell patch- and voltage-clamp recording, high resolution imaging, confocal and electron microscopic and X-ray microanalysis, heterologous protein expression, high performance liquid chromatography neurochemistry, site-directed mutagenesis, in vivo electrophysiological analysis, biomedical engineering techniques, computer simulations and mathematical modeling. Research in the Department of Neurobiology also addresses major issues in neurological health and disease, including epilepsy, primary brain tumors (gliomas), addiction, Alzheimer's disease, Parkinson's disease, Alexander disease, brain/spinal cord injury, mental retardation/developmental disorders, neurodegenerative disorders, movement disorders, perceptual disorders, stroke, and learning and memory disorders.